应用案例｜扫描电子显微镜在药物分析中的应用-医疗器械网

技术中心

当前位置：医疗器械网> 技术中心>应用案例｜扫描电子显微镜在药物分析中的应用

应用案例｜扫描电子显微镜在药物分析中的应用

来源：纳克微束（北京）有限公司分类：行业标准 2024-03-22 15:15:04 21阅读次数

作为一门现代化分析表征技术，扫描电子显微镜具有分辨率高、景深大、制样方法简单的优点，因此在生药（包括植物类生药、动物类与矿物类生药）研究领域的应用越来越广。利用扫描电子显微镜可以表征植物器官表面的细微结构从而对其进行种内品种间的区分，为药材种质资源研究及选育优良品种提供形态区别依据；也可以观察器官表面微细结构从而为正确区分药材提供依据。

黄芩作为植物入药的历史源远流长，早在《本草纲目》中已有记载，它可以去水肿、恶疮、火疡等疾病。而黄芩素是黄芩中含量最高的黄酮类化合物之一，它具有降低脑血管阻力，改善脑血循环、增加脑血流量及抗血小板凝集的作用。

图1 黄芩素纳米花在扫描电镜下结果（ETSE）

药物的形貌、尺寸和分散或黏连情况对其药效影响很大，利用扫描电子显微镜可以轻松获得样品的形貌特征和尺寸结果，并统计其尺寸分布。此外，扫描电镜制样方式很简单，以黄芩素为例，蘸取少许粉末粘在导电胶带上，对其进行喷金处理后即可放进电镜中观察，在FE-1050场发射扫描电子显微镜下可以观察到清晰的黄芩素显微组织形貌，其整体为微米级尺寸的花状结构，该花状结构由几十纳米厚的纳米片聚集而成。

图二、黄芩素纳米花在扫描电镜下结果（ETSE）

图三、黄芩素纳米花在扫描电镜下结果（ETSE）

扫描电镜主要是利用二次电子信号成像来观察样品的表面形貌，相对于透射电镜而言它制样更简单，不需要制作切片和染色就可以直接观察样品的表面或者截面，而且分辨率高，可以轻松获得亚显微结构,，是药物分析中的有力设备。

标签：

参与评论

评论

登录后参与评论

全部评论(0条)

推荐阅读

应用案例｜扫描电子显微镜在药物分析中的应用

作为一门现代化分析表征技术，扫描电子显微镜具有分辨率高、景深大、制样方法简单的优点

 纳克微束（北京）有限公司 21
2024-03-22
无需负染直接观察！科学家用台式透射电子显微镜揭示周围神经病变真相！

无需负染直接观察！科学家用台式透射电子显微镜揭示周围神经病变真相！

QUANTUM量子科学仪器贸易（北京）有限公司 17
2024-02-23
扫描电子显微镜揭示牛奶包装的微结构

利用飞纳台式电镜的低真空成像、自动全景拼图（AIM）和 EDS 元素分析功能探究了牛奶包装的微观结构和密封方式

 复纳科学仪器（上海）有限公司 9
2024-05-16
会议提醒 | 用电子显微镜和X射线微CT揭示电池创新

今晚10点，未注册无回看，先点上！前沿技术不错过。

泰思肯贸易（上海）有限公司 11
2024-04-26
Wiley分析科学直播 | 用电子显微镜和X射线显微CT揭示电池创新

4月25日22:00 专家汇聚，用先进技术揭秘电池材料，为电池开发解锁重要见解。邀您参与！

泰思肯贸易（上海）有限公司 8
2024-04-17
眼见为实 | 扫描透射电镜也可以轻松定位样品和快速BF/DF成像

在扫描透射电子显微镜（STEM）时，您是否曾在定位样品或如何获得最佳图像质量时遇到困难？

泰思肯贸易（上海）有限公司 8
2024-04-24
扫描电镜在碳纳米纤维上的应用

最新的高分辨场发射扫描电子显微镜，colorSEM Apreo 2S配置了三种物镜模式：标准模式、静电物镜模式（搭配镜筒内减速技术）、超高分辨磁浸没模式，应用范围几乎可以覆盖所有固体样品。

北京欧波同光学技术有限公司 14
2024-03-14
喷雾冷冻干燥法在粉体吸入剂颗粒设计中的应用

粉体吸入剂（Dry Powder Inhaler），是将微粉化药物与载体组成的粉体储存于胶囊或泡囊中，经给药装置随着患者吸气实现药物在呼吸系统沉积（主要在肺部）进而发挥药物治疗作用。粉体吸入制剂对COPD（慢性阻塞性肺病）等呼吸系统疾病及时

 东京理化器械株式会社 6
2024-02-22
热点应用丨药品快检好帮手之中药分析——prepASH全自动水分灰分分析仪

在中药的理化分析实验中，水分、酸不溶性灰分和总灰分含量的分析都是重要检测指标之一

 天美仪拓实验室设备（上海）有限公司 5
2024-05-20
热点应用丨如何实现饲料快检——prepASH全自动水分灰分分析仪

在饲料的理化分析实验中，水分、粗灰分含量的分析都是重要检测指标之一，以此来确定饲料的品质和价格。

天美仪拓实验室设备（上海）有限公司 4
2024-05-20

版权与免责声明

①本文由医疗器械网入驻的作者或注册的会员撰写并发布，观点仅代表作者本人，不代表医疗器械网立场。若内容侵犯到您的合法权益，请及时告诉,我们立即通知作者，并马上删除。

②凡本网注明"来源：医疗器械网"的所有作品，版权均属于医疗器械网，转载时须经本网同意，并请注明医疗器械网(www.120med.com)。

③本网转载并注明来源的作品，目的在于传递更多信息，并不代表本网赞同其观点或证实其内容的真实性，不承担此类作品侵权行为的直接责任及连带责任。其他媒体、网站或个人从本网转载时，必须保留本网注明的作品来源，并自负版权等法律责任。

④若本站内容侵犯到您的合法权益，请及时告诉,我们马上修改或删除。邮箱：hezou_yiqi

关于作者

纳克微束（北京）有限公司

作者简介：[详细]

最近更新：2023-09-18 16:20:36

关注私信

更多

最新话题

#医疗反腐#

医疗反腐进行时，北京卫健委原主任获刑11年！

福州市医保局党组书记因涉嫌严重违纪违法，任上被查

最新文章

作者榜

联系我们

400-822-6768 （周一至周五 09:00 ~ 18:00）

服务咨询：932545765

采购服务：2508277101

展会合作：784540580

综合服务：11694366

关注我们

关注微信公众号
120med手机版

沪公网安备 31011502008050号| ICP备案号：沪ICP备16012899| 互联网药品信息服务资格证书| 广播电视节目经营许可证| 营业执照证书

Copyright 2022 120med.com All Rights Reserved , 未经书面授权 , 页面内容不得以任何形式进行复制

基本文件流程错误 SQL 调试

/data/httpd/120med.com/public/index.php ( 0.94 KB )
/data/httpd/120med.com/thinkphp/start.php ( 0.72 KB )
/data/httpd/120med.com/thinkphp/base.php ( 2.60 KB )
/data/httpd/120med.com/thinkphp/library/think/Loader.php ( 21.07 KB )
/data/httpd/120med.com/vendor/composer/autoload_static.php ( 5.37 KB )
/data/httpd/120med.com/vendor/symfony/polyfill-mbstring/bootstrap.php ( 7.07 KB )
/data/httpd/120med.com/vendor/ralouphie/getallheaders/src/getallheaders.php ( 1.60 KB )
/data/httpd/120med.com/vendor/symfony/polyfill-ctype/bootstrap.php ( 1.56 KB )
/data/httpd/120med.com/vendor/symfony/deprecation-contracts/function.php ( 0.98 KB )
/data/httpd/120med.com/vendor/guzzlehttp/promises/src/functions_include.php ( 0.16 KB )
/data/httpd/120med.com/vendor/guzzlehttp/promises/src/functions.php ( 9.89 KB )
/data/httpd/120med.com/vendor/mtdowling/jmespath.php/src/JmesPath.php ( 0.36 KB )
/data/httpd/120med.com/vendor/guzzlehttp/guzzle/src/functions_include.php ( 0.16 KB )
/data/httpd/120med.com/vendor/guzzlehttp/guzzle/src/functions.php ( 5.56 KB )
/data/httpd/120med.com/vendor/danielstjules/stringy/src/Create.php ( 0.55 KB )
/data/httpd/120med.com/vendor/adbario/php-dot-notation/src/helpers.php ( 0.49 KB )
/data/httpd/120med.com/vendor/topthink/think-captcha/src/helper.php ( 1.94 KB )
/data/httpd/120med.com/thinkphp/library/think/Route.php ( 60.23 KB )
/data/httpd/120med.com/thinkphp/library/think/Config.php ( 6.38 KB )
/data/httpd/120med.com/thinkphp/library/think/Validate.php ( 41.63 KB )
/data/httpd/120med.com/vendor/alibabacloud/client/src/Functions.php ( 5.32 KB )
/data/httpd/120med.com/thinkphp/library/think/Error.php ( 3.75 KB )
/data/httpd/120med.com/thinkphp/convention.php ( 10.37 KB )
/data/httpd/120med.com/thinkphp/library/think/App.php ( 21.51 KB )
/data/httpd/120med.com/thinkphp/library/think/Request.php ( 49.78 KB )
/data/httpd/120med.com/application/config.php ( 14.25 KB )
/data/httpd/120med.com/thinkphp/library/think/Env.php ( 1.21 KB )
/data/httpd/120med.com/application/database.php ( 2.10 KB )
/data/httpd/120med.com/thinkphp/library/think/Hook.php ( 4.71 KB )
/data/httpd/120med.com/application/tags.php ( 1.08 KB )
/data/httpd/120med.com/application/common.php ( 44.43 KB )
/data/httpd/120med.com/thinkphp/helper.php ( 17.30 KB )
/data/httpd/120med.com/thinkphp/library/think/Lang.php ( 7.23 KB )
/data/httpd/120med.com/thinkphp/lang/zh-cn.php ( 11.81 KB )
/data/httpd/120med.com/application/route.php ( 10.45 KB )
/data/httpd/120med.com/application/technews/config.php ( 1.22 KB )
/data/httpd/120med.com/application/technews/controller/Index.php ( 3.33 KB )
/data/httpd/120med.com/thinkphp/library/think/Controller.php ( 6.07 KB )
/data/httpd/120med.com/thinkphp/library/traits/controller/Jump.php ( 6.15 KB )
/data/httpd/120med.com/thinkphp/library/think/View.php ( 6.77 KB )
/data/httpd/120med.com/thinkphp/library/think/view/driver/Think.php ( 5.64 KB )
/data/httpd/120med.com/thinkphp/library/think/Template.php ( 44.90 KB )
/data/httpd/120med.com/thinkphp/library/think/template/driver/File.php ( 2.24 KB )
/data/httpd/120med.com/thinkphp/library/think/exception/ErrorException.php ( 1.83 KB )
/data/httpd/120med.com/thinkphp/library/think/Exception.php ( 1.60 KB )
/data/httpd/120med.com/thinkphp/library/think/exception/Handle.php ( 8.44 KB )
/data/httpd/120med.com/thinkphp/library/think/Log.php ( 6.05 KB )
/data/httpd/120med.com/application/technews/service/NewsService.php ( 7.18 KB )
/data/httpd/120med.com/application/common/model/TechNewsCategory.php ( 1.42 KB )
/data/httpd/120med.com/application/common/model/BaseModel.php ( 2.30 KB )
/data/httpd/120med.com/thinkphp/library/think/Model.php ( 69.14 KB )
/data/httpd/120med.com/thinkphp/library/think/Db.php ( 6.67 KB )
/data/httpd/120med.com/thinkphp/library/think/db/connector/Mysql.php ( 3.89 KB )
/data/httpd/120med.com/thinkphp/library/think/db/Connection.php ( 29.97 KB )
/data/httpd/120med.com/thinkphp/library/think/db/Query.php ( 93.74 KB )
/data/httpd/120med.com/thinkphp/library/think/db/builder/Mysql.php ( 4.53 KB )
/data/httpd/120med.com/thinkphp/library/think/db/Builder.php ( 31.55 KB )
/data/httpd/120med.com/thinkphp/library/think/Debug.php ( 7.13 KB )
/data/httpd/120med.com/thinkphp/library/think/model/Collection.php ( 2.27 KB )
/data/httpd/120med.com/thinkphp/library/think/Collection.php ( 10.91 KB )
/data/httpd/120med.com/application/common/model/TechNews.php ( 10.35 KB )
/data/httpd/120med.com/thinkphp/library/think/model/relation/BelongsTo.php ( 7.75 KB )
/data/httpd/120med.com/thinkphp/library/think/model/relation/OneToOne.php ( 10.03 KB )
/data/httpd/120med.com/thinkphp/library/think/model/Relation.php ( 3.61 KB )
/data/httpd/120med.com/application/common/model/UserInfo.php ( 2.32 KB )
/data/httpd/120med.com/application/common/model/Company.php ( 4.93 KB )
/data/httpd/120med.com/thinkphp/library/think/model/relation/HasOne.php ( 7.37 KB )
/data/httpd/120med.com/application/common/model/TechNewsText.php ( 0.22 KB )
/data/httpd/120med.com/thinkphp/library/think/model/relation/HasMany.php ( 9.97 KB )
/data/httpd/120med.com/application/common/model/TechNewsBelongCategory.php ( 0.44 KB )
/data/httpd/120med.com/thinkphp/library/think/Session.php ( 10.86 KB )
/data/httpd/120med.com/application/common/model/UserFollow.php ( 1.59 KB )
/data/httpd/120med.com/application/common/model/product/SeriesProduct.php ( 2.03 KB )
/data/httpd/120med.com/application/common/model/product/BaseProductModel.php ( 1.94 KB )
/data/httpd/120med.com/application/common/model/product/SeriesPicture.php ( 0.35 KB )
/data/httpd/120med.com/application/common/model/TechNewsComment.php ( 2.51 KB )
/data/httpd/120med.com/thinkphp/library/think/db/Expression.php ( 1.11 KB )
/data/httpd/120med.com/extend/org/pscws4/Pscws4.php ( 32.34 KB )
/data/httpd/120med.com/extend/org/pscws4/XDB_R.php ( 4.50 KB )
/data/httpd/120med.com/extend/sphinx/sphinxapi.php ( 51.21 KB )
/data/httpd/120med.com/application/common/model/Topic.php ( 2.97 KB )
/data/httpd/120med.com/application/common/model/TopicInfoList.php ( 4.21 KB )
/data/httpd/120med.com/thinkphp/library/think/model/relation/MorphTo.php ( 9.21 KB )
/data/httpd/120med.com/application/common/model/News.php ( 11.07 KB )
/data/httpd/120med.com/application/common/model/User.php ( 3.16 KB )
/data/httpd/120med.com/application/common/model/Seo.php ( 0.18 KB )
/data/httpd/120med.com/thinkphp/library/think/Cache.php ( 6.10 KB )
/data/httpd/120med.com/thinkphp/library/think/cache/driver/File.php ( 7.27 KB )
/data/httpd/120med.com/thinkphp/library/think/cache/Driver.php ( 5.98 KB )
/data/httpd/120med.com/runtime/temp/b0108cfa51993aa6add40fad2d739741.php ( 25.79 KB )
/data/httpd/120med.com/thinkphp/library/think/Url.php ( 12.72 KB )
/data/httpd/120med.com/application/common/extend/XDeode.php ( 1.87 KB )
/data/httpd/120med.com/thinkphp/library/think/Response.php ( 8.28 KB )
/data/httpd/120med.com/thinkphp/library/think/debug/Html.php ( 4.17 KB )

[8]未定义数组索引: page
[2]Declaration of app\common\model\TechNewsCategory::getList($filter = Array) should be compatible with app\common\model\BaseModel::getList($filter = Array, $sort = Array)
[8]未定义数组下标: 0
[2]Declaration of app\common\model\TechNews::getAllList($filter = Array, $limit = 10, $order = Array, $with = Array) should be compatible with app\common\model\BaseModel::getAllList($filter = Array, $with = Array, $limit = 0, $sort = Array, $field = 'a.*', $join = Array)
[2]Declaration of app\common\model\Company::getAllList($filter = Array, $limit = 20) should be compatible with app\common\model\BaseModel::getAllList($filter = Array, $with = Array, $limit = 0, $sort = Array, $field = 'a.*', $join = Array)
[8]未定义数组索引: center
[8]Only variables should be passed by reference
[2]Declaration of app\common\model\TechNewsComment::getAllList($filter = Array, $limit = 16) should be compatible with app\common\model\BaseModel::getAllList($filter = Array, $with = Array, $limit = 0, $sort = Array, $field = 'a.*', $join = Array)
[8192]Function create_function() is deprecated
[8192]Function create_function() is deprecated
[8]未定义数组索引: area
[8]未定义数组索引: st
[2]Declaration of app\common\model\Topic::getList($filter = Array) should be compatible with app\common\model\BaseModel::getList($filter = Array, $sort = Array)
[2]Declaration of app\common\model\Topic::getAllList($filter = Array, $field = 'id,md5,tit...', $limit = 0) should be compatible with app\common\model\BaseModel::getAllList($filter = Array, $with = Array, $limit = 0, $sort = Array, $field = 'a.*', $join = Array)
[2]Declaration of app\common\model\TopicInfoList::getAllList($filter = Array, $limit = 8) should be compatible with app\common\model\BaseModel::getAllList($filter = Array, $with = Array, $limit = 0, $sort = Array, $field = 'a.*', $join = Array)
[2]Declaration of app\common\model\News::getAllList($filter = Array, $limit = 16, $order = Array, $with = Array) should be compatible with app\common\model\BaseModel::getAllList($filter = Array, $with = Array, $limit = 0, $sort = Array, $field = 'a.*', $join = Array)
[8]未定义数组索引: center
[8]未定义数组索引: cid
[8]未定义数组索引: cid
[8]未定义数组索引: cid
[8]未定义数组索引: cid
[8]未定义数组索引: cid
[8]未定义数组索引: cid
[8]未定义数组索引: cid
[8]未定义数组索引: cid
[8]未定义数组索引: cid
[8]未定义数组索引: goods_list
[8]未定义数组下标: 0
[8]未定义数组索引: center
[8]未定义数组索引: center
[8]未定义数组索引: center
[8]未定义数组索引: center
[8]未定义数组索引: center
[8]未定义数组索引: wtt_list

[ DB ] CONNECT:[ UseTime:0.000339s ] mysql:host=127.0.0.1;port=3306;dbname=120med;charset=utf8
[ SQL ] SHOW COLUMNS FROM `tech_news_category` [ RunTime:0.001017s ]
[ SQL ] SELECT `id`,`name` FROM `tech_news_category` WHERE `is_show` = 1 [ RunTime:0.000239s ]
[ SQL ] SELECT * FROM `tech_news_category` WHERE `parent_id` = 0 AND `is_show` = 1 ORDER BY `sort` ASC,`id` DESC [ RunTime:0.000358s ]
[ SQL ] SHOW COLUMNS FROM `company` [ RunTime:0.000918s ]
[ SQL ] SHOW COLUMNS FROM `tech_news` [ RunTime:0.000733s ]
[ SQL ] SELECT * FROM `tech_news` WHERE `md5` = 'b9c1fedaec1874d1' AND `review_status` = 1 LIMIT 1 [ RunTime:0.000335s ]
[ SQL ] SHOW COLUMNS FROM `user_info` [ RunTime:0.001012s ]
[ SQL ] SELECT * FROM `user_info` WHERE `user_id` = 786 [ RunTime:0.000676s ]
[ SQL ] SELECT * FROM `company` WHERE `id` = 904 [ RunTime:0.000210s ]
[ SQL ] SHOW COLUMNS FROM `tech_news_text` [ RunTime:0.000862s ]
[ SQL ] SELECT * FROM `tech_news_text` WHERE `tech_news_id` = 3025 [ RunTime:0.023910s ]
[ SQL ] SHOW COLUMNS FROM `tech_news_belong_category` [ RunTime:0.000978s ]
[ SQL ] SELECT * FROM `tech_news_belong_category` WHERE `tech_news_id` = 3025 [ RunTime:0.001103s ]
[ SQL ] SELECT * FROM `tech_news_category` WHERE `id` IN (8) [ RunTime:0.000172s ]
[ SQL ] SHOW COLUMNS FROM `user_follow` [ RunTime:0.000931s ]
[ SQL ] SELECT `id` FROM `user_follow` WHERE `user_id` IS NULL AND `follow_user_id` = 786 LIMIT 1 [ RunTime:0.000213s ]
[ SQL ] SHOW COLUMNS FROM `tech_news_comment` [ RunTime:0.000893s ]
[ SQL ] SELECT * FROM `tech_news_comment` WHERE `tech_news_id` = 3025 AND `parent_id` = 0 ORDER BY `id` DESC [ RunTime:0.000226s ]
[ SQL ] SELECT COUNT(*) AS tp_count FROM `tech_news_comment` WHERE `tech_news_id` = 3025 LIMIT 1 [ RunTime:0.000279s ]
[ SQL ] SELECT * FROM `tech_news` WHERE `is_show` = 1 AND `review_status` = 1 AND `id` IN (3025,2491,3903,3659,3445,3608,2828,2467,3961,3960) ORDER BY field(id,3025,2491,3903,3659,3445,3608,2828,2467,3961,3960) [ RunTime:0.000619s ]
[ SQL ] SELECT * FROM `user_info` WHERE `user_id` IN (786,256,610,254,375,300,714) [ RunTime:0.001194s ]
[ SQL ] SHOW COLUMNS FROM `topic` [ RunTime:0.001184s ]
[ SQL ] SELECT `id`,`md5`,`title`,`created_time` FROM `topic` WHERE `review_status` = 1 ORDER BY `id` DESC LIMIT 4 [ RunTime:0.000224s ]
[ SQL ] SHOW COLUMNS FROM `topic_info_list` [ RunTime:0.000861s ]
[ SQL ] SELECT * FROM `topic_info_list` WHERE `topic_id` = 1 ORDER BY `id` DESC LIMIT 2 [ RunTime:0.000213s ]
[ SQL ] SHOW COLUMNS FROM `news` [ RunTime:0.000902s ]
[ SQL ] SELECT * FROM `news` WHERE `id` IN (864,849) [ RunTime:0.000295s ]
[ SQL ] SELECT `id`,`md5`,`title`,`created_time` FROM `tech_news` WHERE `review_status` = 1 AND `is_show` = 1 ORDER BY `id` DESC LIMIT 10 [ RunTime:0.000240s ]
[ SQL ] SHOW COLUMNS FROM `user` [ RunTime:0.000799s ]
[ SQL ] SELECT `a`.* FROM `user` `a` INNER JOIN `tech_news` `b` ON `a`.`id`=`b`.`user_id` GROUP BY `a`.`id` ORDER BY `b`.`id` DESC LIMIT 10 [ RunTime:0.005010s ]
[ SQL ] SELECT * FROM `user_info` WHERE `user_id` IN (592,413,444,224,13,239,598,697,394,285) [ RunTime:0.000820s ]
[ SQL ] SHOW COLUMNS FROM `seo` [ RunTime:0.000859s ]
[ SQL ] SELECT * FROM `seo` WHERE `column_type` = '16' AND `page_type` = 'tech_news' AND `info_id` = 3025 LIMIT 1 [ RunTime:0.000234s ]
[ SQL ] SELECT * FROM `tech_news_belong_category` WHERE `tech_news_id` = 3025 [ RunTime:0.001051s ]
[ SQL ] SELECT * FROM `tech_news_belong_category` WHERE `tech_news_id` = 2491 [ RunTime:0.000905s ]
[ SQL ] SELECT * FROM `tech_news_belong_category` WHERE `tech_news_id` = 3903 [ RunTime:0.000883s ]
[ SQL ] SELECT * FROM `tech_news_belong_category` WHERE `tech_news_id` = 3659 [ RunTime:0.000963s ]
[ SQL ] SELECT * FROM `tech_news_belong_category` WHERE `tech_news_id` = 3445 [ RunTime:0.000918s ]
[ SQL ] SELECT * FROM `tech_news_belong_category` WHERE `tech_news_id` = 3608 [ RunTime:0.001017s ]
[ SQL ] SELECT * FROM `tech_news_belong_category` WHERE `tech_news_id` = 2828 [ RunTime:0.000984s ]
[ SQL ] SELECT * FROM `tech_news_belong_category` WHERE `tech_news_id` = 2467 [ RunTime:0.000986s ]
[ SQL ] SELECT * FROM `tech_news_belong_category` WHERE `tech_news_id` = 3961 [ RunTime:0.000973s ]
[ SQL ] SELECT * FROM `tech_news_belong_category` WHERE `tech_news_id` = 3960 [ RunTime:0.001042s ]
[ SQL ] SELECT * FROM `user` WHERE `id` = 786 LIMIT 1 [ RunTime:0.000168s ]
[ SQL ] SELECT COUNT(*) AS tp_count FROM `user_follow` WHERE `follow_user_id` = 592 LIMIT 1 [ RunTime:0.000202s ]
[ SQL ] SELECT COUNT(*) AS tp_count FROM `user_follow` WHERE `user_id` = 592 LIMIT 1 [ RunTime:0.000146s ]
[ SQL ] SELECT COUNT(*) AS tp_count FROM `user_follow` WHERE `follow_user_id` = 413 LIMIT 1 [ RunTime:0.000181s ]
[ SQL ] SELECT COUNT(*) AS tp_count FROM `user_follow` WHERE `user_id` = 413 LIMIT 1 [ RunTime:0.000166s ]
[ SQL ] SELECT COUNT(*) AS tp_count FROM `user_follow` WHERE `follow_user_id` = 444 LIMIT 1 [ RunTime:0.000128s ]
[ SQL ] SELECT COUNT(*) AS tp_count FROM `user_follow` WHERE `user_id` = 444 LIMIT 1 [ RunTime:0.000320s ]
[ SQL ] SELECT COUNT(*) AS tp_count FROM `user_follow` WHERE `follow_user_id` = 224 LIMIT 1 [ RunTime:0.000129s ]
[ SQL ] SELECT COUNT(*) AS tp_count FROM `user_follow` WHERE `user_id` = 224 LIMIT 1 [ RunTime:0.000124s ]
[ SQL ] SELECT COUNT(*) AS tp_count FROM `user_follow` WHERE `follow_user_id` = 13 LIMIT 1 [ RunTime:0.000155s ]
[ SQL ] SELECT COUNT(*) AS tp_count FROM `user_follow` WHERE `user_id` = 13 LIMIT 1 [ RunTime:0.000233s ]
[ SQL ] SELECT COUNT(*) AS tp_count FROM `user_follow` WHERE `follow_user_id` = 239 LIMIT 1 [ RunTime:0.000223s ]
[ SQL ] SELECT COUNT(*) AS tp_count FROM `user_follow` WHERE `user_id` = 239 LIMIT 1 [ RunTime:0.000151s ]
[ SQL ] SELECT COUNT(*) AS tp_count FROM `user_follow` WHERE `follow_user_id` = 598 LIMIT 1 [ RunTime:0.000244s ]
[ SQL ] SELECT COUNT(*) AS tp_count FROM `user_follow` WHERE `user_id` = 598 LIMIT 1 [ RunTime:0.000203s ]
[ SQL ] SELECT COUNT(*) AS tp_count FROM `user_follow` WHERE `follow_user_id` = 697 LIMIT 1 [ RunTime:0.000148s ]
[ SQL ] SELECT COUNT(*) AS tp_count FROM `user_follow` WHERE `user_id` = 697 LIMIT 1 [ RunTime:0.000178s ]
[ SQL ] SELECT COUNT(*) AS tp_count FROM `user_follow` WHERE `follow_user_id` = 394 LIMIT 1 [ RunTime:0.000153s ]
[ SQL ] SELECT COUNT(*) AS tp_count FROM `user_follow` WHERE `user_id` = 394 LIMIT 1 [ RunTime:0.000348s ]
[ SQL ] SELECT COUNT(*) AS tp_count FROM `user_follow` WHERE `follow_user_id` = 285 LIMIT 1 [ RunTime:0.000136s ]
[ SQL ] SELECT COUNT(*) AS tp_count FROM `user_follow` WHERE `user_id` = 285 LIMIT 1 [ RunTime:0.000135s ]

0.116597s

ShowPageTrace